Korean Journal of Microbiology

Indexed in /covered by CAS, KoreaScience & DOI/Crossref:eISSN 2383-9902   pISSN 0440-2413

Table. 1.

Table. 1.

In vitro and in vivo studies in the field of cancer and postbiotics

In vitro study
Postbiotics Derived postbiotics Cell line Effect References
Cervical cancer
Lactobacillus rhamnosus Cell-free supernatant HeLa Apoptosis Riaz Rajoka et al. (2019)
Lactobacillus casei Cell-free extract Caski, HeLa cells No effect Kim et al. (2015)
Colorectal cancer
Clostridium butyricum Short chain fatty acid HCT-116, Caco-2, HCT-8 Wnt/β-catenin signaling Chen et al. (2020)
Lactobacillus acidophilus Cell-free pentasaccharid Caco-2 Apoptosis El-Deeb et al. (2018)
Lactobacillus acidophilus Cell bound exopolysaccharides HT-29 Autophagy Kim et al. (2010)
Lactobacillus cellobiosus Cell-free supernatant HT-29 Cell proliferation Lim et al. (2006)
Lactobacillus fermentum Cell-free supernatant HT-29, HCT-116 Apoptosis Lee et al. (2019)
Lactobacillus fermentum Cell-free supernatant DLD-1, HT-29, WiDr Apoptosis Lee et al. (2020)
Lactobacillus helveticus Cell-free supernatant HT-29 Cell proliferation Elfahri et al. (2016)
Lactobacillus kefiri Heat-killed HT-29 Apoptosis Brandi et al. (2019)
Lactococcus lactis Cell wall, Cytoplasmic extract SW240 Cell proliferation Hosseini et al. (2020)
Lactobacillus paracasei IMPC2.1
Lactobacillus rhamnosus GG Heat-killed DLD-1 Apoptosis, Orlando et al. (2012)
Lactobacillus pentosus Miny-148 Cell-free supernatant HT-29 Cell cytotoxicity Jung et al. (2009)
Lactobacillus plantarum A7 Heat-killed, cell-free extract Caco-2, HT-29 Cell cytotoxicity Sadeghi-Aliabadi et al. (2014)
Lactobacillus rhamnosus Derived protein, p8 DLD-1 Cell proliferation An et al. (2019)
Propionibacterium Short chain fatty acid HT-29 Cell proliferation Casanova et al. (2018)
Lactic acid bacteria Heat-killed SNUC2A Cell cytotoxicity Kim et al. (2002)
Gastric cancer
Lactobacillus acidophilus 74-2 Cell-free supernatant NCI-N87 Immune Mahkonen et al. (2008)
Lactobacillus paracasei IMPC2.1 Heat-killed HGC-27 Apoptosis, Cell proliferation Orlando et al. (2012)
Helicobacter pylori Heat-killed, Cell-free supernatant MKN45 DNA synthesis Toyoda et al. (2005)
Hepatocellular carcinoma
Lactobacillus acidipiscis, ITA44Lactobacillus pentosus ITA23 Cell-free extract Cell proliferation Salmanzadeh et al. (2018)
Human breast cancer
Brevibacillu Bacteriocin MCF-7 Apoptosis Baindara et al. (2017)
Escherichia coli Cell-free supernatant MCF-7 Apoptosis Bigdeli et al. (2019)
Escherichia coli KUB-36 Short chain fatty acid MCF-7 Anti-inflammatory Nakkarach et al. (2021)
Enterococcus faecalis, Staphylococcus hominis Heat-killed, cytoplasmic fractions MCF-7 Apoptosis,
Cell proliferation Hassan et al. (2016)
Corynebacterium liquefaciens Heat-killed Uchiyama et al. (1978)
Lactobacillus acidophilus Cell-free pentasaccharid MCF-7 Apoptosis El-Deeb et al. (2018)
Lactobacillus acidophilus KP94283, Lactobacillus plantarum KP894100 Heat-killed, cell-free extract MCF-7 Cell cytotoxicity Grange et al. (2008)
Lactobacillus acidipiscis ITA44, Lactobacillus pentosus ITA23 Cell-free extract MDA-MB-23 Cell cytotoxicity Shokryazdan et al. (2017)
Saccharomyces cerevisiae Heat-killed MCF-7, ZR-75-1 Apoptosis Ghoneum and Gollapudi (2004)
Saccharomyces cerevisiae Heat-killed MDA-MB-23 Apoptosis Ghoneum et al. (2008)
Laryngeal cancer
Helicobacter pylori Heat-killed, Cell-free supernatant HEp-2 DNA synthesis Toyoda et al. (2005)
Lung cacner
Mycobacterium indicus pranii Heat-killed, Cell-free supernatant A549, CaSki Apoptosis, Cell cytotoxicity Subramaniam et al. (2016)
Skin cancer
Lactobacillus plantarum L-14 Cell-free extract A375 Apoptosis Park et al. (2020)
In vitro study
Postbiotics Derived postbiotics Animal model Effect References
Colorectal cancer
Lactobacillus casei ATCC334 Derived protein, ferrichrome BALB/c nude mice Apoptosis Konishi et al. (2016)
Lactobacillus plantarum YYC-3 Cell-free supernatant C57BL/6 mice Immune, cytokine Yue et al. (2020)
Lactobacillus rhamnosus Derived protein, p8 BALB/c nude mice An et al. (2019)
Mycobacterium paragordonae Heat-killed C57BL/6 mice Immune, cytokine Lee et al. (2020)
Yoghurt Cell-free extract BALB/c nude mice DMH de Moreno de LeBlanc and Perdigón (2005)
Breast cancer
Lactobacillus helveticus Cell-free fraction BALB/c mice Immune, cytokine de Moreno de LeBlanc et al. (2006)
Pancreatic cancer
Mycobacterium paragordonae Heat-killed C57BL/6 mice Immune, cytokine Lee et al. (2020)
Klebsiella pneumoniae Heat-killed MRL/MpJ mice Autoimmune Kamata et al. (2020)
Korean J. Microbiol. 2021;57:142-53 https://doi.org/10.7845/kjm.2021.1067
© 2021 Korean J. Microbiol.