Korean Journal of Microbiology

Fig. 2.

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Fig. 2. Regulation of cellular amino sugar homeostasis mediated by EIIANtr. In high cellular concentrations of glutamine and α-ketoglutarate, which are nitrogenous organic molecules, EIIANtr exists in a dephosphorylated state. Dephosphorylated EIIANtr cannot bind to GlmS and GlmS is free activated, increasing the concentration of amino sugar GlcN6P. When the nitrogenous organic is depleted, EIIANtr is phosphorylated, inactivating the GlmS after directly binding to it, and the concentration of GlcN6P decreases. This soon activates the Lon protease activity, causing the degradation of EIIANtr, and as a result, GlmS becomes active again.
Korean J. Microbiol. 2022;58:109-19 https://doi.org/10.7845/kjm.2022.2053
© 2022 Korean J. Microbiol.