Korean Journal of Microbiology

Fig. 4.

Download original image
Fig. 4. Regulation of Salmonella virulence program expression by EIIANtr. The expression of the virulence gene of Salmonella is inactivated due to the inhibitory effect of EIIANtr in the early phagosome. After acidification of the phagosome, PhoP and SsrB activation proceed through phosphorylation by PhoQ and SpiR. Subsequently, when the concentration of the intracellular PhoP-P reaches a certain level, the EIIANtr is degraded by the Lon protease, and the additional activity of PhoP and SsrB increases. Consequently, this mediates the expression of the virulence program.
Korean J. Microbiol. 2022;58:109-19 https://doi.org/10.7845/kjm.2022.2053
© 2022 Korean J. Microbiol.