Korean Journal of Microbiology

Table. 4.

Table. 4. Summary of virulence regulation processes controlled by PTS<sup>Ntr</sup>
Organism Phenotype Regulator Mechanism
Pseudomonas aeruginosa Reduction of virulence and resistance to host defense system in ptsP mutants ? EINtr represses expression of QscR, which in turn controls pyocyanin production
EIIANtr is required for biofilm inhibition in the absence of upstream phosphotransfer EIIANtr Unknown
Legionella pneumophila ptsP is required for virulence gene expression in host cells ? Unknown
Salmonella enterica EIIANtr negatively controls SPI-1 and SPI-4 expression and thereby regulates cellular invasion EIIANtr EIIANtr controls propionate catabolism and thereby unstabilizes HilD, which regulates SPI-1 in a post-translational manner
EIIANtr negatively controls SPI-2 expression and thereby regulates pathogenicity EIIANtr EIIANtr prevents the SsrB protein from binding to its target promoter
EIIANtr is required for delay of virulence circuit EIIANtr EIIANtr negatively controls expression of PhoP-regulated genes
Escherichia coli Increased LPS in a ptsO mutant affects biofilm formation NPr Dephosphorylated NPr interacts specifically with LpxD
Hypersensitive phenotype of the ptsP mutant to cellular membrane stress NPr Unknown
Korean J. Microbiol. 2022;58:109-19 https://doi.org/10.7845/kjm.2022.2053
© 2022 Korean J. Microbiol.