Korean Journal of Microbiology

Table. 4. Table 4 Summary of virulence regulation processes controlled by PTS<sup>Ntr</sup>

Organism	Phenotype	Regulator	Mechanism
Pseudomonas aeruginosa	Reduction of virulence and resistance to host defense system in ptsP mutants	?	EI^Ntr represses expression of QscR, which in turn controls pyocyanin production
Pseudomonas aeruginosa	EIIA^Ntr is required for biofilm inhibition in the absence of upstream phosphotransfer	EIIA^Ntr	Unknown
Legionella pneumophila	ptsP is required for virulence gene expression in host cells	?	Unknown
Salmonella enterica	EIIA^Ntr negatively controls SPI-1 and SPI-4 expression and thereby regulates cellular invasion	EIIA^Ntr	EIIA^Ntr controls propionate catabolism and thereby unstabilizes HilD, which regulates SPI-1 in a post-translational manner
	EIIA^Ntr negatively controls SPI-2 expression and thereby regulates pathogenicity	EIIA^Ntr	EIIA^Ntr prevents the SsrB protein from binding to its target promoter
	EIIA^Ntr is required for delay of virulence circuit	EIIA^Ntr	EIIA^Ntr negatively controls expression of PhoP-regulated genes
Escherichia coli	Increased LPS in a ptsO mutant affects biofilm formation	NPr	Dephosphorylated NPr interacts specifically with LpxD
Escherichia coli	Hypersensitive phenotype of the ptsP mutant to cellular membrane stress	NPr	Unknown