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Suppressive effect of Senecio iscoensis Hieron. extract in Propionibacterium acnes-induced inflammatory signaling pathway
Korean J. Microbiol 2019;55(3):206-212
Published online September 30, 2019
© 2019 The Microbiological Society of Korea.

Jin Hak Shin1†, Eun Hye Lee1†, Seon Sook Kim1, Dong-Keun Yi2, Jin Kyung Roh3, and Su Ryeon Seo1*

1Department of Molecular Bioscience, College of Biomedical Science, Institute of Bioscience & Biotechnology, Kangwon National University, Chuncheon 24341, Republic of Korea
2International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea
3Instituto de BioEconomia, El Batan, Quito 170135, Ecuador
Correspondence to: *E-mail:; Tel.: +82-33-250-8541; Fax: +82-33-241-4627
These authors contributed equally to this work.
Received June 10, 2019; Revised June 22, 2019; Accepted June 23, 2019.
Propionibacterium acnes (P. acnes) lives in the hair follicles and pores, and it uses cell debris, sebum and metabolic byproducts of surrounding skin tissues as energy and nutrients. Increased production of sebum due to sebaceous hyperplasia or blockage of the follicle can cause growth and proliferation of P. acnes. The rapid growth of P. acnes in follicles produces cell damage, metabolic byproducts and bacterial chips, which can cause inflammation. In this study, we examined the possibility of Senecio iscoensis Hieron. (S. iscoensis) extract to regulate P. acnes-induced inflammatory signaling pathways. We observed that S. iscoensis extract effectively inhibited P. acnes-induced pro-inflammatory cytokine expressions such as IL-1β, TNF-α, and iNOS in mouse macrophage cell line Raw 264.7. The inhibitory effect of S. iscoensis in pro-inflammatory cytokine levels was accompanied by the inhibition of the transcription factors NF-κB and NF-AT. However, S. iscoensis did not alter the P. acnes-induced MAPK signaling pathways. This study first suggests the potential of using S. iscoensis extract as an alternative agent for the treatment of acne.
Keywords : Propionibacterium acnes, S. iscoensis Hieron., acne, inflammation, pro-inflammatory cytokine

September 2019, 55 (3)
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