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Anti-inflammatory activity of Eurya persicifolia Gagnep. extract in Propionibacterium acnes-induced inflammatory signaling by regulation of NF-κB activity
Korean J. Microbiol 2019;55(3):213-219
Published online September 30, 2019
© 2019 The Microbiological Society of Korea.

Jin Hak Shin and Su Ryeon Seo*

Department of Molecular Bioscience, College of Biomedical Science, Institute of Bioscience & Biotechnology, Kangwon National University, Chuncheon 24341, Republic of Korea
Correspondence to: *E-mail: suryeonseo@kangwon.ac.kr; Tel.: +82-33-250-8541; Fax: +82-33-241-4627
Received July 31, 2019; Revised August 13, 2019; Accepted August 14, 2019.
Abstract
Acne is a chronic inflammatory disease outbreak in the sebaceous glands within the hair follicle. The proliferation of Propionibacterium acnes (P. acnes) causes monocytes to stimulate secretion of inflammatory cytokines. A number of studies proposed the inhibitory effects of P. acnes-mediated inflammation by several natural extracts. However, studies on the effect of Eurya persicifolia Gagnep. (E. persicifolia) extracts on the inflammatory responses by P. acnes have not been explored yet. In this study, we investigated the anti-inflammatory effect of E. persicifolia extract in the inflammatory reactions induced by P. acnes. We found that E. persicifolia extract successfully diminished the expression levels of inflammatory mediators such as IL-1β, IL-6, TNF-α, and iNOS in P. acnes-activated mouse macrophage RAW 264.7 cells. We found that the immunosuppressive effect of E. persicifolia extract in the P. acnes-activated inflammatory signaling is mediated by the regulation of NF-κB transcriptional activation, which is a key regulator of inflammatory cytokine expression. Our results suggest that E. persicifolia extract held potentials for the treatment of P. acnes by suppressing NF-κB signaling pathways.
Keywords : E. persicifolia Gagnep., Propionibacterium acnes, acne, inflammation, pro-inflammatory cytokine


September 2019, 55 (3)
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