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Antimicrobial activity of fraction mixture of ethanol extracts from Eucalyptus globulus, Yucca recurvifolia, and Melaleuca alternifolia against several human skin microbes
Korean J. Microbiol 2019;55(1):46-51
Published online March 31, 2019
© 2019 The Microbiological Society of Korea.

Da-Sol Lee1 , In Kee Hong2 , and Hong-Gyu Song1*

1Department of Biological Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea, 2R&D Center, Radiant Ltd., Chuncheon 24398, Republic of Korea
Correspondence to: E-mail:; Tel.: +82-33-250-8545; Fax: +82-33-259-5665
Received January 25, 2019; Revised February 19, 2019; Accepted February 20, 2019.
This study was carried out to evaluate antimicrobial effects of a mixture of resin fractionated ethanol extract of Eucalyptus globulus, Yucca recurvifolia, and tea tree (Melaleuca alternifolia). The plant fraction mixture showed low minimum inhibitory concentration (0.24~3.32 mg/ml) against several bacteria and yeast that usually used as the target skin microbes in a cosmetic industry, and it was more effective than antibiotics, triclosan and ampicillin. In a time-kill assay the plant fraction mixture reduced more than 92% of microbial populations during 4 h, and significantly increased leakage of nucleotides from all microorganisms tested. Antimicrobial effect of the plant fraction mixture was not affected by divalent cation (Mg2+ and Ca2+). These results suggest that the fraction mixture of ethanol extracts of E. globulus, Y. recurvifolia, and M. alternifolia may be utilized as an efficient preservative in cosmetics to prevent contamination by human skin microbes.
Keywords : Eucalyptus, Yucca, antimicrobial activity, human skin microbes, tea tree

March 2019, 55 (1)
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