Effects of MB-2002 on plasma, liver, and fecal lipid profiles in rats fed a high-cholesterol diet
| ND | HCD | HCD + R | HCD + L | HCD + M | HCD + H | |
|---|---|---|---|---|---|---|
| Plasma | ||||||
| TG (mg/dl) | 57.20 ± 12.45 |
42.28 ± 11.28 | 49.79 ± 14.01 | 41.93 ± 6.66 | 43.09 ± 8.83 | 46.44 ± 5.02 |
| TC (mg/dl) | 74.50 ± 18.63 |
300.0 ± 75.22 | 286.3 ± 59.07 | 241.3 ± 20.04 |
230.3 ± 59.06 |
215.2 ± 32.76 |
| LDL-C (mg/dl) | 19.48 ± 7.58 |
275.5 ± 77.43 | 258.1 ± 65.64 | 209.2 ± 29.06 |
198.0 ± 61.94 |
172.4 ± 35.71 |
| HDL-C (mg/dl) | 43.58 ± 19.94 |
16.00 ± 8.80 | 18.21 ± 8.48 | 22.90 ± 9.87 | 23.65 ± 9.33 | 34.63 ± 8.56 |
| Liver | ||||||
| TG (mg/g) | 3.98 ± 0.43 |
64.59 ± 0.38 | 44.26 ± 7.59 |
59.35 ± 9.40 | 55.54 ± 5.52 | 52.49 ± 2.19 |
| TC (mg/g) | 1.78 ± 0.19 |
30.16 ± 0.94 | 25.93 ± 2.43 | 25.03 ± 3.54 |
24.93 ± 4.03 |
24.59 ± 0.68 |
| Fecal | ||||||
| TC (mg/g) | 2.32 ± 1.21 |
17.6 ± 6.63 | 28.26 ± 4.87 |
26.27 ± 1.19 |
32.52 ± 0.62 |
35.24 ± 2.65 |
| BA (µmol/g) | 12.22 ± 2.45 |
19.11 ± 3.34 | 22.66 ± 3.36 | 23.95 ± 1.63 |
27.40 ± 1.79 |
27.75 ± 1.56 |
Data was expressed as mean ± SD,
ND, Normal diet; HCD, high-cholesterol diet; R, Rosuvastatin; L, MB-2002-L 1 × 108 dead cells/rat; M, MB-2002-M 1 × 109 dead cells/rat; H, MB-2002-H 1 × 1010 dead cells/rat.
TG, triglyceride; TC, total cholesterol; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; BA, bile acid.
a p < 0.05, b p < 0.01, c p < 0.001, d p < 0.0001 compared with the HCD group.